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Newcastle defender Ryan Taylor could miss all of next season after suffering further cruciate ligament damage.
Nuremberg defeated Mainz 2-1 in the Bundesliga on Sunday to deal a blow to theirhopes of a European qualification place.
Barcelona defender Adriano faces up to six weeks on the sidelines after injuring his hamstring.
Sochaux missed the chance to climb back out of the relegation zone after conceding a late equaliser at home to Valenciennes.
Schalke are set to be without injured striker Klaas-Jan Huntelaar for a crucial run of fixtures at home and abroad.
Borussia Dortmund have been rocked by the news that key centre-half Mats Hummels has suffered another injury blow.
Lille have confirmed that captain Rio Mavuba is facing between two and three months on the sidelines.
Real Madrid captain Iker Casillas faces a long spell on the sidelines after fracturing a bone in his hand during Wednesday night's Copa del Rey clash with Valencia.
Ibrahim Afellay has been ruled out of Schalke's Champions League last-16 clash with Galatasaray next month after suffering a torn thigh muscle.
Nice dealt a blow to PSG's title hopes with a 2-1 victory in a game which came to life in the closing 15 minutes.